Immunobiology and immunotherapy of HCC

Soluble Membrane Assault Complicated: Biochemistry and Immunobiology
The soluble membrane assault complicated (sMAC, a.okay.a., sC5b-9 or TCC) is generated on activation of complement and comprises the complement proteins C5b, C6, C7, C8, C9 along with the regulatory proteins clusterin and/or vitronectin.
sMAC is a member of the MACPF/cholesterol-dependent-cytolysin superfamily of pore-forming molecules that insert into lipid bilayers and disrupt mobile integrity and performance. sMAC is a singular complement activation macromolecule as it’s comprised of a number of completely different subunits.
Up to now no complement-mediated perform has been recognized for sMAC. sMAC is current in blood and different physique fluids below homeostatic circumstances and there may be plentiful proof documenting adjustments in sMAC ranges throughout an infection, autoimmune illness and trauma.
Regardless of a long time of scientific curiosity in sMAC, the mechanisms regulating its formation in wholesome people and its organic capabilities in each well being and illness stay poorly understood.
Right here, we assessment the structural variations between sMAC and its membrane counterpart, MAC, and study sMAC immunobiology with respect to its presence in physique fluids in well being and illness. Lastly, we talk about the diagnostic potential of sMAC for diagnostic and prognostic functions and potential utility as a companion diagnostic.
jmicrobiol
jmicrobiol
AAV1 Null Control Virus
AAV-351 50 ?L
EUR 1018
Description: Null (empty) control virus of AAV serotype 1.
AAV2-GFP Control Virus
AAV-302 50 ?L
EUR 1018
Description: GFP control virus of AAV serotype 2.
AAV3-GFP Control Virus
AAV-303 50 ?L
EUR 1018
Description: GFP control virus of AAV serotype 3.
AAV4-GFP Control Virus
AAV-304 50 ?L
EUR 1018
Description: GFP control virus of AAV serotype 4.
AAV5-GFP Control Virus
AAV-305 50 ?L
EUR 1018
Description: GFP control virus of AAV serotype 5.
AAV6-GFP Control Virus
AAV-306 50 ?L
EUR 1018
Description: GFP control virus of AAV serotype 6.
scAAV1-GFP Control Virus
AAV-331 50 ?L
EUR 1018
Description: Self-complementary GFP control virus of AAV serotype 1.
scAAV2-GFP Control Virus
AAV-332 50 ?L
EUR 1018
Description: Self-complementary GFP control virus of AAV serotype 2.
scAAV3-GFP Control Virus
AAV-333 50 ?L
EUR 1018
Description: Self-complementary GFP control virus of AAV serotype 3.
scAAV4-GFP Control Virus
AAV-334 50 ?L
EUR 1018
Description: Self-complementary GFP control virus of AAV serotype 4.
scAAV5-GFP Control Virus
AAV-335 50 ?L
EUR 1018
Description: Self-complementary GFP control virus of AAV serotype 5.
scAAV6-GFP Control Virus
AAV-336 50 ?L
EUR 1018
Description: Self-complementary GFP control virus of AAV serotype 6.
Positive control tissue section for each antibody; Based on availability INQUIRE
Control-Slides Set of 5
EUR 176
AAV1 antibody
10R-2473 5 mL
EUR 459
Description: Mouse monoclonal AAV1 antibody
AAV1 ELISA Kit
55R-PROPRAAV1 96 tests
EUR 1172
Description: ELISA kit for detection of AAV1 in the research laboratory
GFP Expressing Human Glioblastoma Cells
TR01-GFP 500,000 Cells
EUR 1354
AAV1 (intact particle) antibody
10R-2446 50 ug
EUR 583
Description: Mouse monoclonal AAV 1 (intact particle) antibody
AAV2-Cre Control Virus
AAV-310 50 ?L
EUR 1018
Description: Cre control virus of AAV serotype 2.
AAV3-Cre Control Virus
AAV-313 50 ?L
EUR 1018
Description: Cre control virus of AAV serotype 3.
AAV4-Cre Control Virus
AAV-314 50 ?L
EUR 1018
Description: Cre control virus of AAV serotype 4.
AAV5-Cre Control Virus
AAV-315 50 ?L
EUR 1018
Description: Cre control virus of AAV serotype 5.
AAV6-Cre Control Virus
AAV-316 50 ?L
EUR 1018
Description: Cre control virus of AAV serotype 6.
AAV2-Luc Control Virus
AAV-320 50 ?L
EUR 1018
Description: Luciferase control virus of AAV serotype 2.
AAV3-Luc Control Virus
AAV-323 50 ?L
EUR 1018
Description: Luciferase control virus of AAV serotype 3.
AAV4-Luc Control Virus
AAV-324 50 ?L
EUR 1018
Description: Luciferase control virus of AAV serotype 4.
AAV5-Luc Control Virus
AAV-325 50 ?L
EUR 1018
Description: Luciferase control virus of AAV serotype 5.
AAV6-Luc Control Virus
AAV-326 50 ?L
EUR 1018
Description: Luciferase control virus of AAV serotype 6.
AAV2-LacZ Control Virus
AAV-342 50 ?L
EUR 1018
Description: LacZ control virus of AAV serotype 2.
AAV3-LacZ Control Virus
AAV-343 50 ?L
EUR 1018
Description: LacZ control virus of AAV serotype 3.
AAV4-LacZ Control Virus
AAV-344 50 ?L
EUR 1018
Description: LacZ control virus of AAV serotype 4.
AAV5-LacZ Control Virus
AAV-345 50 ?L
EUR 1018
Description: LacZ control virus of AAV serotype 5.
AAV6-LacZ Control Virus
AAV-346 50 ?L
EUR 1018
Description: LacZ control virus of AAV serotype 6.
AAV2 Null Control Virus
AAV-352 50 ?L
EUR 1018
Description: Null (empty) control virus of AAV serotype 2.
AAV3 Null Control Virus
AAV-353 50 ?L
EUR 1018
Description: Null (empty) control virus of AAV serotype 3.
AAV4 Null Control Virus
AAV-354 50 ?L
EUR 1018
Description: Null (empty) control virus of AAV serotype 4.
AAV5 Null Control Virus
AAV-355 50 ?L
EUR 1018
Description: Null (empty) control virus of AAV serotype 5.
AAV6 Null Control Virus
AAV-356 50 ?L
EUR 1018
Description: Null (empty) control virus of AAV serotype 6.
GFP Expressing Human Gastric Carcinoma N87 Cells
TR02-GFP 500,000 Cells
EUR 1354
GFP Expressing Human Renal Adenocarcinoma Cells (ACHN)
TR04-GFP 500,000 Cells
EUR 1354
pCDH-Cuo-RFP-T2A-GFP (positive control virus)
QM350VA-1 >1 x 10^6 IFUs
EUR 636
  • Category: Lentiviral Technology
GFP Expressing Human Prostate Carcinoma Cells (DU 145)
TR03-GFP 500,000 Cells
EUR 1354
pRedZeo-CMV Virus [positive control]
SR10046VA-1 >2 x 10^6 IFUs
EUR 689
  • Category: Stem Cell Products
pRedTK-CMV Virus [positive control]
SR10052VA-1 >2 x 10^6 IFUs
EUR 689
  • Category: Stem Cell Products
pGreenZeo-mCMV Virus [negative control]
SR500VA-1 >2 x 10^6 IFUs
EUR 672
  • Category: Stem Cell Products
pGreenZeo-CMV Virus [positive control]
SR501VA-1 >2 x 10^6 IFUs
EUR 672
  • Category: Stem Cell Products
GFP Lentivirus Control
LTV-300 1 vial
EUR 566
Description: HIV-1 Lentivirus
Influenza A virus HA Control/blocking peptide
AB-23091-P 100ug
EUR 164
Vaccinia virus Complement control protein C3 (VACWR025)
1-CSB-YP302389VAI
  • EUR 679.00
  • EUR 335.00
  • EUR 2172.00
  • EUR 1051.00
  • EUR 1442.00
  • EUR 435.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 28.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Vaccinia virus Complement control protein C3(VACWR025) expressed in Yeast
Green Fluorescent Protein (GFP-fusion protein) ELISA Kit, 96 tests, Quantitative
800-420-GFP 1 kit
EUR 712
pAAV-GFP Control Vector
AAV-400 10 µg
EUR 566
Description: Use this control vector to co-transfect along with AAV packaging vectors to produce a recombinant AAV control.
pscAAV-GFP Control Vector
AAV-410 10 µg
EUR 566
Description: Use this control vector to co-transfect along with AAV packaging vectors to produce a recombinant AAV control.
GFP-Control Protein Vector
PV003 500 ng
EUR 187
Baboon Anti-Rabies Virus IgG antiserum negative control
600-070-03N 1 ml
EUR 164
Baboon Anti-Rabies Virus IgG antiserum positive control
600-070-04P 1 ml
EUR 225
Purified Nipah virus Glycoprotein control for Western Blotting
NIV11-C 100 ul
EUR 286
Purified Nipah virus Nucleoprotein control for Western Blotting
NIV21-C 100 ul
EUR 225
pGreenFire 2.0-CMV positive control virus (pGF2-CMV-rFluc-T2A-GFP-mPGK-Puro)
TR410VA-P >2 x 10^6 IFUs
EUR 697
  • Category: Lentiviral Technology / Reporters
pGreenFire 2.0-mCMV negative control virus (pGF2-mCMV-rFluc-T2A-GFP-mPGK-Puro)
TR411VA-P >2 x 10^6 IFUs
EUR 697
  • Category: Lentiviral Technology / Reporters
pMC.CMV-GFP-SV40PolyA (positive control)
MN601A-1 10 ug
EUR 735
  • Category: Minicircle Technology
GFP inducible control lentiviral particles 
LVP024 1x10e7 IFU/ml x 200ul
EUR 349
Description: Pre-made lentiviral particles expressing codon optimized GFP under tetracycline inducible suCMV promoter. Particles contain a blasticidin-RFP fusion dual marker under the constitutive RSV promoter.
pLenti-GFP Lentiviral Control Vector
LTV-400 100 µL
EUR 618
Description: Use this control vector to co-transfect along with lentivirus packaging vectors to make a recombinant control lentivirus.
pHT10- gfp +control VT Plasmid
PVT5006 2 ug
EUR 325
Human Anti-Mumps Virus (parotitis) IgG negative control serum
520-100-01N 1 ml
EUR 164
Human Anti-Mumps Virus (parotitis) IgG positive control serum
520-100-02P 1 ml
EUR 225
Mouse Anti-Mumps Virus (parotitis) IgG negative control serum
520-130-05N 1 ml
EUR 164
Mouse Anti-Mumps Virus (parotitis) IgG positive control serum
520-130-06P 1 ml
EUR 225
Monkey Anti-Mumps Virus (parotitis) IgG negative control serum
520-160-03N 1 ml
EUR 164
Monkey Anti-Mumps Virus (parotitis) IgG positive control serum
520-160-04P 1 ml
EUR 225
Rhesus Monkey Anti-Rabies Virus IgG antiserum negative control
600-070-01N 1 ml
EUR 164
Rhesus Monkey Anti-Rabies Virus IgG antiserum positive control
600-070-02P 1 ml
EUR 225
Monkey (Cynomolgous) Anti-Rabies Virus IgG antiserum negative control
600-070-05N 1 ml
EUR 164
Cynos Monkey Anti-Rabies Virus IgG antiserum positive control
600-070-06P 1 ml
EUR 225
Camelpox virus H3L/p35 protein control for western blot
CPOX11-C 100 ul
EUR 286
pGreenPuro Scramble Hairpin Control - Virus (for shRNAs and miRZips)
MZIP000-VA-1 >1 x 10^6 IFUs
EUR 716
  • Category: MicroRNA Tools
Mayaro virus (MAYV) Capsid Protein control for Western Blotting
MAYV31-C 100 ul
EUR 286
Mayaro virus (MAYV) nsP1 protein control for Western Blotting
MAYV41-C 100 ul
EUR 286
Mayaro virus (MAYV) 6K Protein control for Western Blotting
MAYV51-C 100 ug
EUR 286
Mayaro virus (MAYV) E3 protein control for Western Blotting
MAYV61-C 100 ul
EUR 286
Control/Blocking peptide for Tobacco Mosaic Virus Movement Protein
TMVMP11-P 100 ug
EUR 164
Zika Virus prM Protein (African) control for Western blot
ZPRM11-C 100 ul
EUR 286
Recombinant Polyoma Virus (KV, Pneumotropic virus) Capsid Protein 1 (VP1) control for Western blot
KVP14-C 100 ul
EUR 286
Camel Anti-Camelpox virus H3L/p35 IgG negative control serum
AE-311170-01N 1 ml
EUR 164
Camel Anti-Camelpox virus H3L/p35 IgG positive control serum
AE-311170-02P 1 ml
EUR 225
Simian virus 5 (starin W3) P/V Control/blocking peptide
AB-23077-P 100ug
EUR 164
Human Anti-Respiratory syncytial virus (RSV) IgG Negative Control Serum
510-300-01N 1 ml
EUR 164
Monkey Anti-Respiratory syncytial virus (RSV) IgG Negative Control Serum
510-325-01N 1 ml
EUR 164
Monkey Anti-Respiratory syncytial virus (RSV) IgG Positive Control Serum
510-325-02P 1 ml
EUR 225
Mouse Anti-Respiratory syncytial virus (RSV) IgG negative control serum
510-345-01N 1 ml
EUR 164
Mouse Anti-Respiratory syncytial virus (RSV) IgG positive control serum
510-345-02P 1 ml
EUR 225
Baboon Anti-Rabies Virus Glycoprotein (RVG) IgG antiserum negative control
600-180-01N 1 ml
EUR 164
Baboon Anti-Rabies Virus Glycoprotein (RVG) IgG antiserum positive control
600-180-02P 1 ml
EUR 225
Influenza A virus (H5N1) matrix protein 2 Control/blocking peptide
M2E15-P 100 ug
EUR 164
Influenza A virus (H1N1) matrix protein 2 Control/blocking peptide
M2E16-P 100 ug
EUR 164
Influenza A virus (H9N2) matrix protein 2 Control/blocking peptide
M2E17-P 100 ug
EUR 164
Bovine Lumpy skin disease virus (LSDV) control for western blot
LSDV11-C 100 ul
EUR 286
pSIF1-H1-siLuc-copGFP Positive Transduction Control (pre-packaged virus)
LV201B-1 >1 x 10^6 IFUs
EUR 699
  • Category: Lentiviral Technology
Bovine Anti-Lumpy skin disease virus (LSDV) negative control serum
RV-500700-01N 1 ml
EUR 164
Bovine Anti-Lumpy skin disease virus (LSDV) positive control serum
RV-500700-02P 1 ml
EUR 225
Recombinant Rat sialodacryoadenitis Virus (SDAV) nucleoprotein control for Western blot
SDAV11-C 100 ul
EUR 286
Rabies Virus Glycoprotein (~58 kda, RVG) control for western blot
RBVGP11-C 100 ul
EUR 286
EF1a Control lentiviral particles (GFP-Bsd)
EF1a-Null-GB 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Blasticidin fusion marker under RSV promoter.
EF1a Control lentiviral particles (GFP-Puro)
EF1a-Null-GP 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Puromycin fusion marker under RSV promoter.
CMV Control lentiviral particles (GFP-Bsd)
CMV-Null-GB 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Blasticidin fusion marker under RSV promoter.
CMV Control lentiviral particles (GFP-Puro)
CMV-Null-GP 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Puromycin fusion marker under RSV promoter.
GFP-Null fusion control lentiviral particles
Null-G-(Puro) 1x107 IFU/ml x 200ul
EUR 349
Description: Pre-made GFP-Null fusion Control lentivirus containing puromycin marker. GFP fusioned with a non-targeting Null sequence for evenly fluorescent signal distribution. Virus contains a Puromycin selection marker.
GFP-RFP fusion control lentiviral particles
LVP442 1x10e7 IFU/ml x 200ul
EUR 451
Description: Pre-made lentiviral particles expressing GFP-RFP fusion contruct under suCMV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.
SUMO-GFP (Multi-Protease Control Protein)
M1072-250
EUR 576
SUMO-GFP (Multi-Protease Control Protein)
M1072-50
EUR 180
pSMPUW-GFP-Puro Lentiviral Control Vector
LTV-401 10 µg
EUR 618
Description: Use this control vector to co-transfect along with lentivirus packaging vectors to make a recombinant control lentivirus.
Monkey/Chimp Anti-Zaire Ebola virus glycoprotein (GP) IgG positive control
AE-320650-PC 2 ml
EUR 225
Baboon Anti-Rabies Virus Nucleoprotein (RV-NP) IgG antiserum negative control
600-660-01N 1 ml
EUR 164
Baboon Anti-Rabies Virus Nucleoprotein (RV-NP) IgG antiserum positive control
600-660-02P 1 ml
EUR 225
NATtrol BK Virus External Run Control, Low (6 X 1 mL)
NATBK-ERCL 6 X 1 mL
EUR 339.12
  • What is the product classification?
  • NATtrol BK Virus External Run Control, Low is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
NATtrol BK Virus External Run Control, Medium (6 X 1 mL)
NATBK-ERCM 6 X 1 mL
EUR 401.52
  • What is the product classification?
  • NATtrol BK Virus External Run Control, Medium is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
NATtrol Zika Virus (PRVABC59), External Run Control, Medium (6 x 1.0mL)
NATZIKV(PRV)-ERCM 6 x 1.0mL
EUR 391.12
  • What is the product classification?
  • NATtrol Zika Virus PRVABC59), External Run Control, Medium is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
NATtrol Zika Virus, External Run Control, Low (6 x 1 mL)
NATZIKV-ERCL 6 x 1 mL
EUR 330.8
  • What is the product classification?
  • NATtrol Zika Virus, External Run Control, Low is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
NATtrol Zika Virus, External Run Control, Medium (6 x 1 mL)
NATZIKV-ERCM 6 x 1 mL
EUR 391.12
  • What is the product classification?
  • NATtrol Zika Virus, External Run Control, Medium is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
Purified Pseudorabies Virus glycoprotein B (PsRV gB) control for western blot
PSRVGB11-C 100 ul
EUR 286
Respiratory Syncytial Virus (RSV) Rapid Test Control Pack (2 X 1.5mL)
KZMC034 RSV Rapid Test Control Pack
EUR 97.84
  • What is the product classification?
  • Respiratory Syncytial Virus is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
Recombinant Lymphocytic choriomeningitis virus (LCMV) Nucleoprotein (NP) control for Western blot
LCMV14-C 100 ul
EUR 286
Porcine Pseudorabies Virus glycoprotein B (PsRV gB) antibody negative control serum
RV-400400-PNC 1 ml
EUR 164
Porcine Pseudorabies Virus glycoprotein B (PsRV gB) antibody positive control serum
RV-400400-PPC 1 ml
EUR 225
Bovine Viral Diarrhea Virus 2 E2 (BVDV2E2) IgG negative control serum
RV-500100-03N 1 ml
EUR 164
Bovine Viral Diarrhea Virus (BVDV1-3) Erns IgG negative control serum
RV-500200-01N 1 ml
EUR 164
Bovine Viral Diarrhea Virus (BVDV1-3) Erns IgG positive control serum
RV-500200-02P 1 ml
EUR 225
Rat Anti-Rat sialodacryoadenitis Virus (SDAV) nucleoprotein antibody negative control serum
SDAV11-RNC 1 ml
EUR 164
Rat Anti-Rat sialodacryoadenitis Virus (SDAV) nucleoprotein antibody positive control serum
SDAV11-RPC 1 ml
EUR 225
Mouse Anti-Mouse Pneumonia Virus (PVM) nucleoprotein antibody negative control serum
PVMNP11-MNC 1 ml
EUR 164
Mouse Anti-Mouse Pneumonia Virus (PVM) nucleoprotein antibody positive control serum
PVMNP11-MPC 1 ml
EUR 225
Rat Anti-Mouse Pneumonia Virus (PVM) nucleoprotein antibody negative control serum
PVMNP12-RNC 1 ml
EUR 164
Rat Anti-Mouse Pneumonia Virus (PVM) nucleoprotein antibody positive control serum
PVMNP12-RPC 1 ml
EUR 225
Recombinant purified Mouse Pneumonia Virus (PVM) nucleoprotein control for Western blot
PVMNP14-C 100 ul
EUR 286
Mouse Anti-Sendai/(SeV/Parainfluenza virus 1) antibody negative control serum
SEND11-MNC 1 ml
EUR 164
Mouse Anti-Sendai/(SeV/Parainfluenza virus 1) antibody positive control serum
SEND11-MPC 1 ml
EUR 225
Rat Anti-Sendai/(SeV/Parainfluenza virus 1) antibody negative control serum
SEND12-RNC 1 ml
EUR 164
Rat Anti-Sendai/(SeV/Parainfluenza virus 1) antibody positive control serum
SEND12-RPC 1 ml
EUR 225
Chicken Anti-Sendai/SeV/Parainfluenza virus 1 antibody negative control serum
SEND13-CNC 1 ml
EUR 164
Chicken Anti-Sendai/SeV/Parainfluenza virus 1 antibody positive control serum
SEND13-CPC 1 ml
EUR 225
Recombinant Zika Virus Envelop domain III (African) control for Western blot
ZEND21-C 100 ul
EUR 286
Control siRNA Vector (pGB-control)
9500C-20
EUR 338
GFP inducible control lentiviral particles in PBS
LVP024-PBS 5x107 IFU/ml x 200ul
EUR 710
Description: Pre-made lentiviral particles expressing codon optimized GFP under tetracycline inducible suCMV promoter. Particles contain a blasticidin-RFP fusion dual marker under the constitutive RSV promoter, provided in PBS solution
Recombinant African Swine fever virus (ASFV) P30 protein control for western blot
ASFV11-C 100 ul
EUR 286
Bovine Viral Diarrhea Virus 1 (BVDV1) Erns Protein control for western blot
BVDR12-C 100 ul
EUR 286
Human Anti-Tai Forest virus glycoprotein (TAFV-GP) IgG negative control serum
AE-325620-01N 1 ml
EUR 164
Human Anti-Tai Forest virus glycoprotein (TAFV-GP) IgG positive control serum
AE-325620-02P 1 ml
EUR 225
Human Anti-Vesicular Stomatitis Virus Glycoprotein, Indiana (VSVIG) IgG negative control serum
AE-327310-01N 1 ml
EUR 164
Human Anti-Vesicular Stomatitis Virus Glycoprotein, Indiana (VSVIG) IgG positive control serum
AE-327310-02P 1 ml
EUR 225
Monkey Anti-Vesicular Stomatitis Virus Glycoprotein, Indiana (VSVIG) IgG negative control serum
AE-327320-01N 1 ml
EUR 164
Monkey Anti-Vesicular Stomatitis Virus Glycoprotein, Indiana (VSVIG) IgG positive control serum
AE-327320-02P 1 ml
EUR 225
Recombinant Zaire-Ebola virus nucleoprotein (Mayinga EBOV NP) protein control for Western
EVNP11-C 100 ul
EUR 286
Recombinant (E.Coli) Japanese Encephalitis Virus (JEV) prM protein control for Western blot
JEV13-C 100 ul
EUR 286
NATtrol Epstein Barr Virus (EBV) Strain:B95-8,External Run Control-Medium(6X1mL)
NATEBV-ERCM 6X1mL
EUR 391.12
  • What is the product classification?
  • NATtrol Epstein Barr Virus EBV) Strain:B95-8,External Run Control-Medium is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
NATtrol Zika Virus (PRVABC59), External Run Control, Low (6 x 1.0 mL)
NATZIKV(PRV)-ERCL 6 x 1.0 mL
EUR 330.8
  • What is the product classification?
  • NATtrol Zika Virus PRVABC59), External Run Control, Low is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
Purified recombinant Porcine epidemic diarrhea virus Nucleoprotein (PEDV-NP) WB positive control
PEDV11-C 100 ul
EUR 347
Poliomyelitis Virus 1 Viral Protein 1 control/blocking peptide (Sabin; POLV1-VP1)
POL1VP111-P 100 ug
EUR 164
Poliomyelitis Virus 2 Viral Protein 1 control/blocking peptide (Sabin; POLV2-VP1)
POL2VP121-P 100 ug
EUR 164
Poliomyelitis Virus 3 Viral Protein 1 control/blocking peptide (Sabin; POLV3-VP1)
POL3VP131-P 100 ug
EUR 164
Influenza A virus (H5N1) matrix protein 2 hybrid sequence Control/blocking peptide
M2E11-P 100 ug
EUR 164
Mouse Anti-Lymphocytic choriomeningitis virus (LCMV) Nucleoprotein (NP) antibody negative control serum
LCMV11-MNC 1 ml
EUR 225
Mouse Anti-Lymphocytic choriomeningitis virus (LCMV) Nucleoprotein (NP) antibody positive control serum
LCMV11-MPC 1 ml
EUR 225

Immunobiology and immunotherapy of HCC: highlight on innate and innate-like immune cells

Immune-based therapies equivalent to immune checkpoint inhibitors have revolutionized the systemic therapy of assorted most cancers varieties. The therapeutic software of monoclonal antibodies focusing on inhibitory pathways equivalent to programmed cell death-1(PD-1)/programmed cell demise ligand 1 (PD-L1) and CTLA-Four to cells of the adaptive immune system has just lately been proven to generate significant enchancment within the medical consequence of hepatocellular carcinoma (HCC).
Nonetheless, present immunotherapeutic approaches induce sturdy responses in solely a subset of HCC sufferers. Since immunologic mechanisms equivalent to continual irritation as a consequence of continual viral hepatitis or alcoholic and nonalcoholic fatty liver illness play an important position within the initiation, improvement, and development of HCC, it is very important perceive the underlying mechanisms shaping the distinctive tumor microenvironment of liver most cancers.
The liver is an immunologic organ with massive populations of innate and innate-like immune cells and is uncovered to bacterial, viral, and fungal antigens via the gut-liver axis. Right here, we summarize and spotlight the position of those cells in liver most cancers and suggest methods to therapeutically goal them.
We additionally talk about present immunotherapeutic methods in HCC and description current advances in our understanding of how the therapeutic potential of those brokers is likely to be enhanced.

Peripheral blood T lymphocytosis in thymoma: an perception into immunobiology

Objective: Peripheral blood T lymphocytosis (PBTL) is a uncommon, but poorly understood manifestations of thymoma, which is postulated to be linked with autoimmune/paraneoplastic manifestations equivalent to myasthenia gravis (MG), pure purple cell aplasia (PRCA), and so on.; extra generally encountered on this neoplasm.

Methodology: We goal to explain the flowcytometric immunophenotypic information of PBTL in a 43-year-old male; 6 months after profitable completion of chemoradiotherapy (CT/RT) for a big, invasive, and metastatic sort B1 thymoma; and current a complete assessment of all such circumstances reported over final 42 years (N = 21) (1977-2019).

Consequence: A bigger dimension of the tumors (≥ 10 cm), presence of native invasion and/or distant metastasis, and sort B (cortical or lymphocyte wealthy) histology have been extra prone to be related to PBTL.

Tumors related to MG/PRCA (N = 9/21) are inclined to have decrease PBTL in comparison with these with out such manifestations; and PBTL subsided following thymectomy with or with out CT/RT. Immunophenotypic evaluation of PB revealed a CD8 + > CD4 + mature (naïve) polyclonal T cells resembling late cortical thymocytes.

Conclusion: Thymic intratumoral microenvironment may affect prevalence PBTL which will have a pathophysiologic hyperlink to the improvement of autoimmune manifestations. Immunophenotypic traits of peripheral blood lymphoid cells must be the clue for correct characterization and to keep away from a misdiagnosis of a lymphoproliferative neoplasm.
Immunobiology of Acquired Resistance to Ticks
Ticks are blood-sucking arthropods of nice significance within the medical and veterinary fields worldwide. They’re thought-about second solely to mosquitos as vectors of pathogenic microorganisms that may trigger severe infectious issues, such as Lyme borreliosis and tick-borne encephalitis.
Onerous (Ixodid) ticks feed on host animals for a number of days and inject saliva along with pathogens to hosts throughout blood feeding. Some animal species can purchase resistance to blood-feeding by ticks after a single or repeated tick infestation, leading to decreased weights and numbers of engorged ticks or the demise of ticks in subsequent infestations. Importantly, this acquired tick resistance (ATR) can scale back the danger of pathogen transmission from pathogen-infected ticks to hosts.
That is the premise for the event of tick antigen-targeted vaccines to forestall tick infestation and tick-borne ailments. Accumulation of basophils is detected within the tick re-infested pores and skin lesion of animals exhibiting ATR, and the ablation of basophils abolishes ATR in mice and guinea pigs, illustrating the essential position for basophils within the expression of ATR.
On this assessment article, we offer a complete overview of current advances in our understanding of the mobile and molecular mechanisms accountable for the event and manifestation of ATR, with a specific concentrate on the position of basophils.
T-cell immunobiology and cytokine storm of COVID-19
2019 coronavirus illness (COVID-19) presents as a newly acknowledged pneumonia and will quickly progress into acute respiratory misery syndrome which has caused a worldwide pandemic. Till now, no healing remedy has been strongly beneficial for COVID-19 apart from personalised supportive care.
T cells and virus-specific T cells are important to guard in opposition to virus an infection, together with COVID-19. Delayed immune reconstitution (IR) and cytokine storm (CS) stay severe obstacles for the remedy of COVID-19.
Most COVID-19 sufferers, particularly amongst aged sufferers, had marked lymphopenia and elevated neutrophils, however T cell counts in extreme COVID-19 sufferers surviving the illness step by step restored later.
Elevated pro-inflammatory cytokines, notably IL-6, IL-10, IL-2, and IL-17, and exhausted T cells are present in peripheral blood and the lungs. It means that Thymosin α1 and adoptive COVID-19-specific T cells may enhance IR whereas convalescent plasma, IL-6 blockade, mesenchymal stem cells, and corticosteroids may suppress CS.
Extra medical research on this subject worldwide are urgently warranted to pave the best way for remedy of COVID-19 sooner or later.

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