State Medical Academy, Regional Clinical Hospital, Kirov, Russia
It is showed that HAV+HBV mixed infection is a genetically determined pathology. Following HLA-antigens were immunogenetic markers of the disease: HLA-A10, B21, Cw2, Cw5, A10-A19, B8-B13, B21-B35, A3-B21, A9-B21. Lower risk of disease development was associated with HLA-B5, A2-Cw3, A3-Cw4, B35-Cw4, A3-B35-Cw4. Atypical forms of the hepatitis A were often met in carriers of HLA-Cw5, B27-B35, A3-B14, A3-B21, A9-B21, whereas typical forms — in carriers of HLA-A10, Cw2, A10-A19, B8-B13, B21-B35. Mild forms of hepatitis A were associated with the presence of HLA-A10, B22, A10-A19, B8-B13, A3-B21, A9-B8, A10-B14, A10-B22, A10-Cw3 in the patients’ phenotype, whereas intermediate and severe forms — with the presence of HLA-B17, B17-B18, B21-B35, A28-B21, B18-Cw2. The findings about distribution of HLA-antigens and their combinations in mixed hepatitis A+B can be used in attempt of their prediction and prevention.
Zh. Mikrobiol. (Moscow), 2007, No. 3, P. 30—34