Volokh, O.A., Shepelev, I.A., Firstova, V.V., Khramkova, E.M., Avdeeva, N.G., Samokhvalova, Yu.I., Yeremin, S.A., Dyatlov, I.A., Zhemchugov, V.E.

Evaluation of immunobiological activity of Francisella tularensis C-complex preparations as promising component of subunit vaccines

Russian Research Institute for Plague Control “Microbe”, Saratov; State Scientific Centre of Applied Microbiology and Biotechnology, Obolensk, Moscow region, Russia

Data on influence of Francisella tularensis C-complex preparations on formation of immunity against tularemia are presented. Study of cellular immunity characteristics as well as dynamics of antibody response was carried out on white mice and guinea pigs models. Absence of toxicity, pyrogenicity, and negative effects on immunocompetent cells in combination with protective activity points to possibility of use the C-complex as a component of a subunit vaccine.
Zh. Mikrobiol. (Moscow), 2007, No. 3, P. 16—21

Volokh, O.A., Shepelev, I.A., Firstova, V.V., Khramkova, E.M., Avdeeva, N.G., Samokhvalova, Yu.I., Yeremin, S.A., Dyatlov, I.A., Zhemchugov, V.E. Evaluation of immunobiological activity of Francisella tularensis C-complex preparations as promising component of subunit vaccines

Volokh, O.A., Shepelev, I.A., Firstova, V.V., Khramkova, E.M., Avdeeva, N.G., Samokhvalova, Yu.I., Yeremin, S.A., Dyatlov, I.A., Zhemchugov, V.E.

Evaluation of immunobiological activity of Francisella tularensis C-complex preparations as promising component of subunit vaccines