Institute of Biochemistry and Physiology of Plants and Microorganisms, State Medical University, Saratov, Russia
Impact of Azospirillum brasilense Sp7 lectin with carbohydrate specificity to L-fucose on T- and B-lymphocytes production, activity of IL-1α, and TNF-α was studied in vitro and compared with influence of red kidney bean phytohemagglutinin (PHA) on the same parameters. Increase of growth of T- and B-cells subpopulations has been shown that point to stimulatory effect of the bacterial lectin. Bacterial lectin of A.brasilense also increased synthesis of IL-1α and TNF-α. It has been shown that the bacterial lectin has more pronounced stimulatory effect on functional activity of lymphocytes compared with PHA.
Zh. Mikrobiol. (Moscow), 2007, No. 2, P. 60—65