Khaziev, A.F., Mikhailova, N.A.

Molecular mechanisms of cytotoxic effect of α-toxin of Stapylococcus aureus

Scientific-production association “Immunopreparation”, Ufa; Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia

Mechanism of action of Staphylococcus aureus α-toxin has been reviewed. Data about molecular transformations during cytolytic action, dimensional structure of monomeric and oligomeric toxin, its characteristics in different molecular states are presented. Data about defects of oligomerization due to modification or site-induced mutagenesis are discussed.
Zh. Mikrobiol. (Moscow), 2007, No. 1, P. 77—83