Mechnikov Resarch Institute of Vaccines and Sera, Gamaleya Research Institute of Epidemiology and Microbiology, Blokhin Oncological Research Center, Moscow, Russia
Effect of immunomodulators for microbial origin on i
ate immunity and antitumor system was continued to study. Immunomodificator Immunovac VP-4, purified staphylococcal toxoid and glucosaminyl muramyl dipeptide (GMDP) equally enhanced cytotoxicity of mononuclear leukocytes of peripheral blood of healthy donors. Index of cytotoxicity was 2.78, 2.77 and 2.70 respectively. Reduced metastatic progression of Lewis lung carcinoma in mice was observed after Immunovac VP-4 and GMDP administration. Effectiveness was seen when preparations administered according to schedules including their administration before implantation of the tumor. If preparations were administered number of metastases reduced in 4.4 — 5.6 times and size of metastases reduced in 7 — 10 times. Interplay between antitumor activity of studied immunomodulators and cytotoxic activity of NK-cells, which are base effectors of antitumor immune response, are discussed.
Zh. Mikrobiol. (Moscow), 2006, No. 6, P. 35—40