Research Institute of Epidemiology and Microbiology, Vladivostok, Russia
The comparative investigation of resident macrophage oxygen-dependent and nitric oxide-dependent enzymic system in Staphylococcus and Listeria infections characterizing by different microbial phagocytosis ways was conducted. The study demonstrated that in initial stages of infections the reaction of peritoneal macrophage enzymic system depended upon species and the virulence degree of bacteria. The oxygen-dependent system had the basic importance for the causative agent killing in Staphylococcus infection, whereas this function in Listeria infection was realized by the nitric oxide-dependent system of macrophages. The degree of activation of respiratory chain enzymes was expressed more with avirulent strains in L.monocytogenes and S.aureus infections. It has been supposed that virulent strains of these bacteria inhibit the activity of respiratory chain enzymes (succinodehydrogenase, lactic dehydrogenase, cytochromoxidase, NADPH-oxidase complex) and the associated macrophage bactericidal ability. Perhaps it should be attributed to one of the effects by the virulence factors of Staphylococcus and Listeria.
Zh. Mikrobiol. (Moscow), 2006, No. 3, Supplement, P. 39—43