Institute of Highly Pure Biopreparations, St. Petersburg; Gamaleya Research Institute of Epidemiology and Microbiology; Sechenov Medical Academy, Moscow, Russia
The regulation of definite bacterial genes is known to occur, depending on the density of cell population, on the principle of autoinduction named “quorum sensing”. The characteristic sign of all regulatory systems working on the principle of “quorum sensing” is the presence of two regulatory proteins: LuxI-like, responsible for the binding of its autoinductor, which makes it possible for the newly formed complex to bind with the promoter of the specific target gene and activate its transcription. The phenomenon of a rise in the concentration of the secreted autoinductor, depending on the increase of the density of cell culture which forms the basis of the “quorum sensing” systems, is analyzed with a view to the development of new therapeutic remedies.
Zh. Mikrobiol. (Moscow), 2006, No. 3, P. 105—113