Urals State Medical Academy, Regional Center of Sanitary and Epidemiological Surveillance, Yekaterinburg, Russia
The formation of immunity and epidemiological effectiveness of inactivated influenza vaccines in children, regularly immunized against influenza for three years, were evaluated. The study revealed that a year after each immunization the number of children having antibodies in liters regarded as protective decreased 2—2.5 times. At the periods of epidemics morbidity rate among the vaccines dynamically decreased in these years 1.3, 2.0 and 2.8 times. Considering that a year after the second immunization a high immune stratum (60—78%) was retained in the group under study, we propose that a
ual immunization of the same children be limited by a period of three years, followed by an interval of one year.
Zh. Mikrobiol. (Moscow), 2002, No. 4, P. 36—39