Agafonov, V.E., Mitereva, D.E., Makarova, O.V., Agafonov, E.P.

Morphofunctional characterization of mast cells of the skin and the mucous membrane of airways in specific hyposensitization, carried out on an experimental model

Mechnikov Research Institute for Vaccines and Sera, Research Institute of Human Morphology, Moscow, Russia

The study of the morphofunctional state of the population of guinea-pig mast cells in response to the action of specific allergen was carried out. The mast cells of different guinea pigs, intact and sensitized, as well as those hyposensitized by two methods, the classical method and the method combining extracorporeal and oro- pharyngeal hyposensitization, were compared. As shown in this study, after specific hyposensization the tendency towards the normalization of the morphofunctional state of the mast-cell population in the airway walls and the skin was noted.
Zh. Mikrobiol. (Moscow), 2006, No. 2, P. 61—65