Andzhaparidze Research Institute of Viral Preparations, Moscow, Russia
The influence of human and mouse cytokines on the induction of immune response to model T-independent (TI) antigens of type 2 — DNP-dextran and DNP-ficoll — in the culture of mouse spleen cells was studied. For the first time this study revealed that the action of definite T-cell factors not only induced the polyclonal stimulation of B lymphocytes, but also the increased synthesis of specific antibodies, as well as switched over antibody isotypes from IgM to IgG. This confirmed the suggestion that T cells took part (directly or indirectly) in the regulation of immune response to so-called TI antigens. These results widened our knowledge on the mechanisms of the development of humoral immune response to TI antigens of type 2.
Zh. Mikrobiol. (Moscow), 2006, No. 1, P. 44—47