State Medical University, Gomel, Belarus
The comparison of the levels of some cytokines (tumor necrosis factor a (TNF-α), IL-1β, IL-2, IL-4) in the blood serum of patients with chronic hepatitis C (CHC) having different antibody spectrum was carried out. In CHC patients increased levels of the serum cytokines IL-1β, TNF-α under study in comparison with cytokine levels in donor sera was noted. In patients with detected antiNS5 and antiHCV IgM and antiNS5 HCV the level of IL-1β was significantly higher than that in CHC patients without antibodies in sera. A change in the levels of proinflammatory and anti-inflammatory cytokines in the blood sera of CHC patients may be of significant diagnostic and prognostic importance.
Zh. Mikrobiol. (Moscow), 2005, No. 5, P. 103—105