Zemskov, A.M., Zemskov, V.M., Zemskov, M.A., Zoloedov, V.I., Bolotskikh, V.I.

Problem of specific and nonspecific factors in the induction and regulation of immunological reactions

Burdenko State Medical Academy, Voronezh; Research Institute “BINAR”, Moscow, Russia

The functional unity of the specific and nonspecific mechanisms of immunological reactions has been shown on the basis of our own investigations and the published data. As revealed in this study, during the formation of immune response smooth transition from the nonspecific level to the specific one occurs. First, the factors of nonspecific protection are switched on, then intermediate reactions develop, further antibodies are synthesized, etc. At any level of immune response its regulation by nonspecific immunomodulators is possible, their influence controlled by a complex of reactions of the neuroendocrine system, also carrying the elements of nonspecificity and specificitynZh. Mikrobiol. (Moscow), 2005, No. 4, P. 105—109