Mechnikov Research Institute for Vaccines and Sera, Research Institute of Pediatrics, Moscow, Russia
The effectiveness and safety of vaccination of children having chronic inflammatory lung diseses with Pneumo-23 and Act-HIB were evaluated. The group under study included 38 children having chronic pneumonia, congenital defects of lung development, Kartagener’s syndrome, mucoviscidosis; of these children, 25 were vaccinated with Pneumo-23 and 13 — with Act-HIB. For comparison a group of 40 children with the same pathology, but not vaccinated, was used. A favorable course of the postvaccinal period was noted. Prior to vaccination Streptococcus pneumoniae in association with Haemophilus influenzae were isolated from all patients; in a year after vaccination with Pneumo-23 these microorganisms were isolated only in monoculture: S.pneumoniae in 3 out of 25 cases (88% elimination) and H.influenzae in 10 out of 25 cases (60% elimination).
Zh. Mikrobiol. (Moscow), 2005, No. 3, P. 84—87