Kuzin, S.N., Zaplatnikov, A.L., Ibragimova, F.A., Skvortsova, N.N., Nechepurenko, L.A., Raengulov, B.M., Volova, L.Yu., Popov, M.T., Makarenko, I.V., Karpova, T.F., Reshetnyak, V.V., Krivtsova, G.G., Varlamova, I.A., Kuzina, L.E., Malyshev, N.A., Zverev,

Evaluation of the immunogenic and reactogenic properties of vaccine “Euvax B” in persons aged 16–18 years in different geographical zones of Russia

Research Institute of Viral Preparations, Medical Academy of Advanced Studies, Moscow; State Sanitary and Epidemiological Surveillance Center of the Yamalo-Nenets Autonomous District, Salekhard; Infectious Clinical Hospital No. 1, Moscow, Russia

The comparative evaluation of the reactogenic and immunogenic properties of vaccine “Euvax B” in adolescents aged 16 — 18 years was carried out in factory housing estate Lvovsky, the Podolsk district, the Moscow region, and in the Yamalo-Nenets Autonomous District (AD): in towns Salekhard, Noyabrsk, Muravlenko, in housing estate Tarko-Sale. The evaluation demonstrated that the use of this vaccine in a dose of 20 мg/ml produced no postvaccinal complications and the frequency of postvaccinal reactions was insignificant. Postvaccinal anti-HBs were detected, on the average, in protective concentrations in 98.4±1.8% of the vaccines (99.0±1.9% in the Moscow region, 97.7±3.2% in the Yamalo-Nenets AD). In most of the vaccinated adolescents high concentrations of postvacinal anti-HBs were detected: in 51.4±9.7% of the vaccinees in the Moscow region and in 89.7±6.4% in the Yamalo-Nenets AD they exceeded 1,000 I.U./lit. The conclusion was made that in the territories located in subarctic latitudes vaccinal prophylaxis against hepatitis B was safe and highly effective and have no limitations co

ected with the conditions of the Far North.
Zh. Mikrobiol. (Moscow), 2005, No. 2, P. 41—44