Mechnikov Research Institute for Vaccines and Sera, Central Research Institute of Gastroenterology, Moscow, Russia
The monitoring for the presence of H.pylori carrier state in a group of patients with gastric and duodenal ulcer was carried out with subsequent determination of the relationship between the intensity of the urease activity of the bioptic specimen of the mucous membrane and the severity of the course of the disease. For this purpose we developed the scheme for the evaluation of the severity of the disease with quantitative criteria. The data obtained in this work showed no correlation between the severity of this disease and usease activity. Still the method of the quantitative determination of the urease activity of the bioptic specimen made it possible to evaluate the rate of the production of hydroxyl anions by a given H.pylori strain and thus quickly establish the presence of carrier state.
Zh. Mikrobiol. (Moscow), 2005, No. 1, P. 68—70