Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia
Mechanisms of the immunomodulating and anticancerogenic action of bacteria of the genus Lactobacillus are updated on the basis of recent publications andown research. The impact of lactobacteria on the production of cytokines by the host as one of the most important factors mediating the modulating properties of these microorganisms is considered. Information on the capacity of lactobacteria to exhibit stimulating and suppressing effects on the immune system, to maintain the development and support oral tolerance and to ensure antitumor action is presented. The role of different cell components of lactic acid bacteria in inducing the cytokines synthesis is discussed. The mechanisms of the immunomodulating action of different probiotic preparations for the prophylaxis and correction of immunodeficient states associated with the development of dysbacteriosis and acute enteric infections are analyzed. The data on the oncostatic action of bacteria of the genus Lactobacillus are presented.
Zh. Mikrobiol. (Moscow), 2004, No. 6, P. 101—106