Karyagina, A.S., Naroditsky, B.S., Apt, A.S., Gintsburg, A.L.

Genomics and gene engineering: rationale to the development of new means of tuberculosis control

Gamaleya Research Institute of Epidemiology and Microbiology, Central Research Institute of Tuberculosis, Moscow, Russia

The review contains information on modern approaches to the development of antituberculosis vaccines and remedies. Data on the comparative effectiveness of different subunit and DNA vaccines against tuberculosis are presented. The use of comparative and structural genomics for the search and characterization of new Mycobacterium tuberculosis genes, whose products may prove to be important antigens for the development of vaccines or target proteins for remedies against tuberculosis, is considered.
Zh. Mikrobiol. (Moscow), 2004, No. 4, P. 94—101