Delvig,A.A., Semenov,B.F.

Invariable chain (Ii-chain) as a highly important molecular shaperon of histocompatibility class II molecules

Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia

The publications on the structural and functional features of the main molecular shaperon of Ii-chain were updated. In the 1990s the determination of molecular shaperon as a group of mutually unrelated protein molecules taking part in the assembly of other polypeptides was worked out. In humans the main isoform of Ii-chain is the protein with a mol. wt. of 31-33 kD. A great variety of functions of this shaperon is linked with definite amino acid sequences. In particular, the molecular shaperon of the molecules of the main histocompatibility complex-II has functions co

ected with the presentation of antigen and the differentiation of B lymphocytes.
Zh. Mikrobiol. (Moscow), 2004. No. 2, P. 99—106