State Medical University, State Medical Academy, Republican Clinical Oncologic Dispensary, Kazan, Russia
106 patients with diagnostically confirmed gastric cancer, adenomatous and hyperplastic polyp, inflammatory hyperplastic erosion, focal hypertrophy of the gastric mucosa were examined for the presence of H.pylori infection. A high detection rate of H.pylori in chronic and neoplastic diseases of the stomach was noted. Malignant and benign tumors of the stomach were found to be accompanied by a high degree of contamination of the gastric mucosa. From patients with adenocarcinoma, dysplasia and intestinal metaplasia H.pylori adhesive strains were mainly isolated. The adhesiveness of the isolated H.pylori strains was 60.97±1.2%, most frequently to sheep red blood cells (75.2%) and human red blood cells (70.4%), less frequently to horse red blood cells (53.4%). The result of the hemagglutinating test was positive in adenocarcinoma, dysplasia, metaplasia more often than in hyperplasia and chronic inflammation. Contamination with H.pylori highly adhesive strains may, probably, serve as one of the possible factors contributing to the development of neoplastic processes in the gastric muosa.
Zh. Mikrobiol. (Moscow), 2003, No. 6, P. 6—11