Zakharova,N.S., Agaltsova,S.I., Shmeleva,E.I., Britsina,M.V., Ozeretskovskaya,M.N., Remova,T.N., Bazhanova,I.G., Mertsalova,N.U., Ermolova,E.V.

Morphological changes in the organs of animals after the injection of acellular pertussis vaccine with immunomodulator

Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia

Toxic properties of acellular pertussis vaccine (APV) and morphological changes in white mice in response to intramuscular injection of APV (without or with immunomodulator glucosaminylmuramyl dipeptide-GMDP) were under study. APV used in these experiments was developed at the Mechnikov Research Institute for Vaccines and Sera (the Russian Acad. Med. Sci.) on the basis of Bordetella pertussis cultures in synthetic fluid culture media. In experiments on acute and chronic toxicity of APV (without GMDP) increased tissue immunity reactions in spleen, thymus, liver, lungs and intestinal wall was detected. There was no difference in immunomorphological reactions in mice receiving APV with different doses of GMDP, but some difference was observed in time dynamics of tissue immunity reactions. A small dose of GMDP should be preferred (0.0001 mg) which results in gradual growth of tissue immunity reactions less pronounced toxic reactions caused be the APV injection.
Zh. Mikrobiol. (Moscow), 2003, No. 3, P. 30—34