Institute of Cellular and Intracellular Symbiosis, Orenburg; Bashkir Medical University, Ufa; Medical Academy, Chelyabinsk, Institute of Ophthalmic and Plastic Surgery, Ufa, Russia
Data on the apoptosis phenomenon with enterobacteria used as a model are presented. One of the mechanisms regulating the vital activity of eukaryotic cells is, together with cell proliferation and differentiation, the phenomenon known as “apoptosis”. This physiological process of the eukaryotic cells death is used by many parasites in parasite — host relationships in different epitopes. The system known to trigger programmed cell death, is the surface receptor Fas, the receptor of tumor necrosis factor (TNFα) activated by the corresponding FasL ligand and TNFα, which further triggers the cascade mechanisms of the execution program. In various representatives of enterobateria different proteins serve as Fas ligand, viz. protein IpaB in Shigella flexneri, SipB activating converting enzyme IL-1β, identical to capsase-1, in Salmonella spp., YopP in Yersinia spp. Still the mechanism triggering apoptosis in Yersinia spp. has some original features. In Escherichia coli α-hemolysin is the factor triggering the suicidal program, the triggering mechanism being mediated by an increase in intracellular calcium ions.
Zh. Mikrobiol. (Moscow), 2002, No. 1, P. 79—84