Bekhalo, V.A., Sysolyatina, E.V., Nagurskaya, E.V.

Mechanisms of Chlamydia trachomatis and herpes simplex virus persistence during viral-bacterial infection

Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia

Possible mechanisms of persistence on the example of Chlamydia trachomatis in conditions of herpes simplex virus type 2 (HSV-2) superinfection in vitro and in vivo are described. Emergence of persisting forms of Chlamydia as well as factors influencing on this process are considered. Contemporary views on pathogenesis of viral-bacterial infection with HSV-2 and C.trachomatis as well as interactions of the agents with local immunity factors are described. It was suggested that there are signaling pathways through which HSV-2 changes life cycle of Chlamydia.
Zh. Mikrobiol. (Moscow), 2009, No. 5, P. 105—110