Institute of Cellular and Intracellular Symbiosis, Orenburg; Orenburg State Medical Academy, Orenburg, Russia
Aim. To substantiate the possibility to use the biological characteristics of microorganism, in particular, factors of its persistence, for assessment of severity of trophic ulcers of lower extremities. Materials and methods. Clinical examinations and bacteriological tests of 48 patients aged from 37 to 80 years with trophic ulcer of lower limbs were performed. Antilysozyme, anticomplement, anticarnosine as well as hemolytic activity of isolated microorganisms were assessed. Results. It was established that microflora of trophic ulcers of lower limbs are diverse and microorganisms were isolated both in monoculture and in associations, with maximal significance of Staphylococcus aureus. Analysis of biological properties of microflora isolated in patients with various courses of trophic ulcers of lower limbs allowed to determine roles of antilysozyme, anticomplement, anticarnosine and hemolytic activities in severity of the illness. Conclusion. Performed studies allowed to develop diagnostic models for prediction of severity course of trophic ulcers of lower limbs.
Zh. Mikrobiol. (Moscow), 2009, No. 4, P. 111—114