Timchenko, N.F., Terentyeva, N.A., Pokrovsky, V.K., Terentyev, L.L., Nedashkovskaya, E.P., Rasskazov, V.A.

Influence of thermolabile lethal toxin of Yersinia pseudotuberculosis on development of sea urchin embryos and biosynthesis of DNA and RNA in embryonic cells

Research Institute of Epidemiology and Microbiology; Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia

Influence of thermolabile lethal toxin of Y.pseudotuberculosis on the development of embryos of sea urchin (Strongylocentrotus intermedius) and on biosynthesis of nucleic acids in embryonic cells was studied. Thermolabile lethal toxin affected metabolic processes of cells by inhibiting DNA and RNA synthesis. It had damaging action on developing embryos of sea urchin causing morphological changes and, as a consequence, death of embryos.
Zh. Mikrobiol. (Moscow), 2008, No. 6, P. 66—69