Shchukovskaya, T.N., Klueva, S.N., Kravtsov, A.L., Kozlova E.A., Kutyrev, V.V.

Modulating effect of serotonin on the development of human leukocytes apoptosis induced by Yersinia

Russian Research Institute for Plague Control “Mic­robe”, Saratov, Russia

Effect of biogenic amine serotonin on the development of human blood leukocytes during interaction with species from Yersinia genus (Y.pestis EV, Y.pseudotuberculosis serovars I and IV, Y.enterocolitica serovars O9 and O3) was studied in model system in vitro using flow cytofluorometry. Serotonin in concentration 10^-5 M had differently marked effects on Yersinia spp.-induced apoptosis of leukocytes. Pattern of the observed changes depended from species and serovar of Yersinia. Serotonin inhibited development of early (after 6 hours) apoptosis of leukocytes induced by Y.pestis and Y.pseudotuberculosis serovar I.
Zh. Mikrobiol. (Moscow), 2008, No. 6, P. 43—46