Regional Children’s Clinical Hospital, Nizhny Novgorod; Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia
Medical history, immunization status were studied and serologic tests were performed in 72 children aged 1 ― 16 years (mean age 10.8±0.49 years) with rheumatic diseases (juvenile rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, Overlap-syndrome, etc.). Three hundred people aged 3 ― 26 years belonging to indicator groups were included in the control group. Real protection was achieved in 77.8% of patients with rheumatic diseases. Sixteen patients (22.2%) did not have protective antibody titers, of which 5 were not vaccinated. From children with rheumatic diseases received 1 dose of vaccine 14.8% (4 out of 27) were seronegative, whereas from those received 2 doses 22.5% (9 out of 40) were seronegative. Difference in mean optical density (OD) of serum samples obtained in children from control group, which received 1 or 2 doses of vaccine, was not observed (Δ1.02ｱ0.16 and Δ0.74ｱ0.09 respectively). Decline of antibody titers with time after vaccination in children with rheumatic diseases immunized with 2 doses of vaccine was observed (r=-0.42, P=0.008).
Zh. Mikrobiol. (Moscow), 2008, No. 5, P. 95—98