Branch 48 of Central Research Institute of Ministry of Defense of Russian Federation — Center of Virology, Sergiev Posad, Russia
Development of the theory and practice of building and maintenance of collections of reference cultures of pathogens strains is actual in conservation of a biodiversity, and as for maintenance with standardized superfine starting materials fundamental and applied researches in fields of microbiology, an immunology, biotechnology, ecology, and biosafety. Various approaches to taxonomy of viruses, and also definition of concepts "strain" and "species" are discussed in the article. Formulations of the concepts most conforming to museum collections ac-tivity are given. The methodology of collecting pathogens, including fifteen-year experience of maintenance of the National collection of hemorrhagic fever viruses belonging to group I of pathogenicity, is summarized. The sys-temic approach is suggested as a basis of methodology of collecting. Selection of pathogen species and their specific strains according to purpose and on the basis of complex study of their biological and other characteris-tics, as well as standardization and unification of methods of pathogens maintenance and preparing on their basis working materials, diagnostic kits and other preparations, create a real basis of optimization, unification and conti-nuity of the subsequent applied researches. The offer about formation at the state level of a new independent direction — pathogens collecting with establishment of federal centers based on pathogens’ classes has been made.
Zh. Mikrobiol. (Moscow), 2007, No. 6, P. 84—93