Research Institute of Molecular Medicine, Sechenov Moscow Medical Academy, Institute of Human Morphology, Moscow, Rus-sia
Increasing interest to heat shock proteins (HSP) from biologists and medics is connected to widespread distri-bution of HSP in live nature and reflects their key role in support of life functions which is based on the unique polyfunctionality of these biomolecules. Together with main function, which is defense of biologic systems from stress effects, some HSP in the process of evolution acquired the ability to incorporate in the reactions of the im-mune system. The in vestmen of this protein in practical reactions of innate immunity system are described. Analysis of mechanisms underlying the adjuvant effect of pro- and eukaryotic HSP in innate immunity system is presented. HSP receptor structures on target cells as well as triggered intracellular signaling pathways are de-scribed.
Zh. Microbiol. (Moscow), 2007, No. 5, P. 97—106