State Medical Academy, Nizhny Novgorod, Russia
Contribution of intracellular signal pathways associated with nuclear factor κB (NF-κB) in realization of interac-tions of human neutrophils and epithelial cells from oral cavity with Candida albicans was studied. Supression of NF-κB in epitheliocytes resulted in decreased adsorption of C.albicans to buccal cells (buccal mucosa). Inhibition of NF-κB led to decrease in receptor-dependent oxidative activity of neutrophils in systems with native and IgG-opsonized C.albicans as well as to increase of phagocytic activity during contact with C3b-/iC3b-opsonized C.albicans. It has been concluded that NF-κB participates in regulation of specific interactions of neurophils and epitheliocytes with C.albicans.
Zh. Microbiol. (Moscow), 2007, No. 5, P. 61—65