Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia
Concept of construction of new type of vaccines for inducing rapid nonspecific immunological protection against pathogens by activation of i
ate immunity mechanisms has been formulated. Materials about formula of the concept, theses of theory of i
ate immunity, and experimental and clinical data, which confirm the concept, are presented. Results of studies with recombinant proinflammatory cytokines and synthetic ligands for Toll-like receptors as well as with polycomponent vaccine containing antigens of opportunistic bacteria (Immunovac VP-4) are also presented. Obtained data allowed to assume that activation of i
ate immunity mechanisms by preparations carrying pathogen-associated and molecular structures of microorganisms can result in formation of rapid and nonspecific protection against any pathogen.
Zh. Mikrobiol. (Moscow), 2007, No. 4, P. 93—100